Pectin isa soluble fibre, which cannot be absorbed into the body. Apolysaccharide, the body cannot break it down into its constituent molecules. Typically, it is found in the cell wall of plants, vegetables and fruits - like apples, carrots and in the peel of citrus fruit and plums. Lau ES, Liu E, Paniagua SM, Sarma AA, Zampierollo G, López B, et al. Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension. JACC Basic Transl Sci. 2021 Jan 6;6(1):12–21. DOI: 10.1016/j.jacbts.2020.10.006. PMID: 33532663. PMCID: PMC7838053.

Within the galectin family, Gal-3 has unique properties. It is a beta-galactoside-binding protein involved in a wide array of biological processes, mainly related to cell cycle, immunity and injury repair. Gal-3 is found in the nucleus, cytoplasm, mitochondrion, fibroblasts, cell surface and extracellular matrix. Circulating Gal-3 levels increase with age, injury and chronic illness.Cold showers are a great way to introduce your body to the benefits of cold exposure therapy. Read our article for the full guide... J. Ibarrola, et al., “Galectin-3 Down-Regulates Antioxidant Peroxiredoxin-4 in Human Cardiac Fibroblasts: A New Pathway to Induce Cardiac Damage,” Clin. Sci. (Lond). 132(13), 1471–1485 (2018). A randomized controlled trial involving 87 patients with IBS and diarrhea symptoms showed that those who took daily pectin had significantly fewer symptoms, more formed stools, and better quality of life than those who took placebo.

I. Eliaz, E. Weil and B. Wilk, “Integrative Medicine and the Role of Modified Citrus Pectin/Alginates in Heavy Metal Chelation and Detoxification — Five Case Reports,” Forsch Komplementmed. 14(6), 358–364 (2007). Clinical Synergy® Professional Formulas Santa Rosa, CA 95401 877.877.2362 [email protected] There were also no negative side effects observed in a clinical trial involving children with lead toxicity in China. For three months, the hospitalized children between the ages of 5 and 12 were given 15 g of MCP in three divided doses a day [ 4].

Select store

ProstaCaid® — The combination of PectaSol with ProstaCaid provides up to 40% greater benefits for prostate cellular health, compared to using either product alone.* While there’s no cause for alarm, potential health concerns around EMFs make it worthwhile to increase your EMF protection when it’s practical to do... Abnormal angiogenesis and diversion of pre-existing blood vessels are crucial in neoplastic as well as inflammatory and fibrotic conditions, as these processes provide the nutrients and oxygen needed to sustain otherwise hypoxic environments 95. Interestingly, the glycome of ECs varies considerably in response to immunosuppressive or hypoxic stimuli, which favour exposure of galectin-specific glycan epitopes 9. Several galectin family members have pro-angiogenic activity as a result of their capacity to bind distinct glycosylated receptors on the EC surface 96. For example, GAL1 interacts with complex N-glycans on vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) and promotes receptor phosphorylation followed by activation of the AKT and ERK1/2 signalling pathways, thus preserving vascularization in tumours that are resistant to anti-VEGF treatment 9 (Fig. 2). These actions link tumour hypoxia to aberrant angiogenesis pathways identified in melanoma as well as lung, prostate and pancreatic adenocarcinoma 9, 78, 97, 98, 99, 100, 101. Likewise, interactions with the transmembrane glycoprotein, neuropilin 1 (NRP1) are essential for GAL1-driven angiogenesis and induction of vascular permeability 102, 103 (Fig. 2). Recently, an alternative mechanism was proposed whereby GAL1 regulates angiogenesis through binding to the mRNAs of angiogenesis-related factors, including VEGF-A, early growth response 1 protein (EGR1) and α 5 laminin 104. F. Sanchis-Gomar, et al., “Galectin-3, Osteopontin and Successful Aging,” Clin. Chem. Lab. Med. 54(5), 873–877 (2016).